Senior Director

The Senior Director of Drug Metabolism and Pharmacokinetics (DMPK) reports to the Vice President of Quantitative Pharmacology group. In partnership with drug discovery medicinal chemists, biologists, pharmacologists and toxicologists, you will be responsible for leading a small team of DMPK scientists supporting multiple projects from target identification through to candidate selection and ultimately regulatory submission.

1. Provide DMPK scientific leadership across all stages of the portfolio.
2. Oversee the quality and performance of all DMPK activities including interactions with external CRO’s and internal project stakeholders.
3. Work collaboratively with other core disciplines to support compound progression based on optimizing DMPK properties.
4. Integrate data from multiple sources to inform on the understanding of bicyclic peptide distribution, metabolism and excretion.
5. Work closely with in-vivo pharmacology to design experiments to understand preclinical pharmacokinetic/pharmacodynamic (pk/pd) relationships.
6. Work closely with discovery team and regulatory team to author and review DMPK related IND documents
7. Managing DMPK budgets for CRO’s and monitoring CROs to ensure delivery of quality data on time.
8. Support leadership of the Quantitative Pharmacology group and junior staff development

Requirements

Essential:

1. PhD in relevant scientific discipline such as drug metabolism, pharmacology, pharmaceutical sciences.
2. Significant experience working on DMPK drug discovery and/or development projects with a track record of successful delivery.
3. In depth understanding of DMPK science with additional knowledge of related disciplines.
4. Demonstrated expertise in DMPK problem solving across drug discovery.
5. Ability to adapt your working style to suit different cultures and partner expectations in both remote and office-based environment.
6. Excellent organisation and communication skills, both written and oral, with the ability to influence.

Desirable:

1. Previous experience working on peptides-macrocycles would be an advantage.
2. Nice-to-have: experience on radio-pharm projects