Director, Gene Editing Technologies

SUMMARY:

Generation Bio is seeking a motivated and highly skilled individual to lead platform development of gene editing technologies. This is a director-level position, that reports to the VP, Head of molecular biology. This is a pivotal position within our organization, responsible for leading scientific strategy and technical planning for development of editing technologies. The successful individual will have demonstrated technical expertise and advanced molecular understanding of gene editing technologies broadly, including nuclease and recombinase systems. The candidate will have a track record of building teams and managing cross functional projects successfully. Success in this role includes working cross functionally to integrate development of editing cargo with ctLNP technology for delivery to target tissue. Additionally, the position affords the opportunity for broader impact on cargo engineering efforts across generation Bio including development of iqDNA for episomal and insertional gain of function applications.

RESPONSIBILITIES:

• Build and lead team to develop editing technologies for therapeutic application
• Spearhead and lead design approaches for development of editing technologies
• Accountable for on-time execution of experimental projects to advance our editing platform
• Provide scientific input to influence and shape company objectives and strategy
• Work cross functionally to execute on project objectives, integrate results across project teams and coordinate resources to maximize synergy
• Access and synthesize different sources of information (papers, patents, consultants) to set scientific strategy for meeting platform technology goals

QUALIFICATIONS:

• PhD in Molecular Biology, Synthetic biology, Bioengineering, Biochemistry or related discipline
• Minimum of 10 years of relevant experience, 3 years specifically working on gene editing applications
• Experience engineering/ optimizing editing systems for improved performance and function
• In-depth mechanistic understanding of diverse gene editing technologies (including gene correction and replacement) and their therapeutic application.
• Understanding of DNA repair systems important for driving specific editing outcomes
• Deep understanding of emerging editing strategies including large gene insertion and/or engineered recombinases a plus
• Capacity for strong strategic thinking and critical problem solving
• Proven leadership experience with record of building and developing high performance teams.
• Excellent communication and interpersonal skills with capacity to work internally and externally to forward company goals.

POSITION: Full-Time, Exempt