Scientist, Protein Engineering

We are looking for an innovative Scientist to join our R&D team. The successful candidate will create novel solutions to evolving market needs utilizing the world-class DNA synthesis, assembly and NGS tools internally available at Twist. The ideal candidate has strong technical fundamental knowledge in NGS, synthetic biology or a related field with a strong publication record to support that.

Responsibilities

• Independently lead novel research projects by designing, performing experiments and analyzing subsequent data.
• Coalesce abstract concepts into tangible goals and outcomes.
• Design and perform molecular biology experiments, including plasmid vector design, construction and cloning.
• Innovate and create screening assays for DNA/RNA modifying enzymes.
• Develop quantitative biochemical and quality control assays to characterize DNA/RNA modifying enzymes and enzyme systems.
• Document experimental results, communicate data and outcome to stakeholders.
• Stay updated on relevant scientific literature, trends and products.
• Contribute to conceptualizing invented technologies as products to the genomics market.

Qualifications and Required Skills

• Ph.D. or a M.S with 5+ years of experience in Molecular Biology, Biochemistry, Chemistry or closely-related fields. Relevant post-doctoral or industrial experience is preferred
• Strong background in fundamental molecular biology techniques including DNA/RNA purification and quantification, PCR/qPCR, Molecular cloning, Enzymatic assays and Next Generation Sequencing (NGS).
• Experience in any one or more of the following: enzyme engineering, cell-free protein expression, RNA or single-cell sequencing
• High attention to detail around determining complex experimental strategies including experimental design, execution, analysis, troubleshooting and review of new methods to facilitate product concept development
• Strong knowledge and expertise in genomic sciences
• Ability to draw conclusions, formulate hypotheses and determine next steps based on collected data to solve novel problems.
• Dynamic interpersonal skills. Respectful and open to others’ views; contribute to building a positive team spirit.
• Self-motivated, willing to learn and be up-to-date on current scientific literature or new research developments
• Comfortable working in a fast-paced environment with occasional exploratory research projects that provide better understanding of an existing problem

Preferred Skills

• Experience with various NGS library preparation techniques and hands-on experience using NGS sequencing platforms. Experience with WGS and illumina technologies preferred.
• Experience with genome alignment, variant calling, annotation.
• Experience with one or more specialized molecular biology aspects (i.e. specific knowledge towards DNA/RNA modifying enzymes, cell-free protein expression, protein engineering).
• Programming experience (ideally Python) for manipulating and analyzing large datasets.

About Twist Bioscience

Twist Bioscience synthesizes genes from scratch, known as “writing” DNA. Just as children learn to both read and write, the next phase of development for the genomics revolution is the ability to write DNA.

At Twist Bioscience, we work in service of people who are changing the world for the better. In fields such as health care, agriculture, industrial chemicals and data storage, our unique silicon-based DNA Synthesis Platform provides precision at a scale that is otherwise unavailable to our customers.

Twist Bioscience Corporation is an Equal Opportunity Employer. Twist Bioscience Corporation provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, genetic characteristics, or any other category protected by law.