Senior Protein Engineer Scientist

Job Description

General Summary:

Our Seattle site is seeking a talented and motivated Protein Engineer (Senior Scientist) to join our dynamic team. If you are passionate about advancing scientific research and developing novel therapeutics, this role is for you!

Key Duties and Responsibilities:

• Design and execute protein engineering/directed evolution campaigns to improve binding affinity, stability, and selectivity.
• Utilize yeast surface display technology for library screening and directed evolution.
• Drawing from a deep array of Rosetta scripts and machine learning tools, create computational design strategies to deliver protein drug candidates.
• Effectively communicate design strategies to interdisciplinary team members.
• Collaborate with cross-functional teams to optimize protein candidates for function, manufacturability, and immunogenicity.
• Prepare reports, papers, and patent applications, collaborating closely with inventors, scientists, and legal counsel.

Knowledge and Skills:

• Strong understanding of the biophysics of protein structure/function relationships
• Proven experience in directed evolution, yeast surface display, and protein engineering.
• Demonstrated proficiency in protein modeling and design utilizing Rosetta software suite, Alphafold2, ColabFold, Protein MPNN, RFdiffusion or equivalent tools for insilico protein engineering
• Strong analytical skills and attention to detail
• Excellent communication and teamwork abilities
• Familiarity with antibody engineering and affinity maturation
• Experience in cellular assay development
• Understanding of cell biology and immunology

Education and Experience:

• Ph.D. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 2-5 years of relevant post-doctoral, industry employment experience, or
• M.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 5+ years of relevant industry employment experience, or
• B.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 8+ years of relevant industry employment experience

This position will be based out of our Seattle site location focused on protein engineering for the organization. Over the past 9 years we have utilized protein engineering to create a robust pipeline including Acazicolcept (ALPN-101) and Povetacicept (ALPN-303)

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Flex Designation:

On-Site Designated

Flex Eligibility Status:

In this On-Site designated role, you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com