Associate Director/Principal Scientist

SUMMARY:

Generation Bio is seeking an energetic and highly motivated Associate Director/Principal Scientist to join the Immunology Group. The position will play a key role in development and evaluation of our cell targeted lipid nanoparticle (ctLNP) delivery platform by devising and executing a strategic plan aimed at evaluating ctLNPs interacting with immune cells. The successful candidate will have a depth of experience performing in vitro experiments with primary human immune cells and assay development. The candidate will support the execution and provide direction to scientists conducting vitro PoC and MOA assays using human and/or murine immune cells to further facilitate evaluation of ctLNP and novel target biologies. The ideal candidate will have experience executing in vivo small animal pharmacology studies related to the exploration of immunology in areas of disease related to immunology such as oncology or autoimmunity. The candidate is expected to have a firm grasp of human T cell biology and the design and analysis of complex multicolor flow cytometry endpoints. The candidate will have strong communication skills and be adept at working cross functionally and collaboratively with scientists and stakeholders.

RESPONSIBILITIES:

• Conceptualize experimental path to evaluate novel target biology and design PoC in vitro experiments
• Contribute to the strategic thinking of novel target concepts
• Design and execute in vivo pharmacology studies in WT and disease models
• Analyze and report data, synthesizing key results and crafting strategic path forward
• CRO management in collaboration with preclinical operations group
• Project leadership, responsible for balancing resources and executing on deliverables, with the ability to influence, design, and scope out new project initiatives in a matrixed team
• Mentor direct reports and other scientists within the group

QUALIFICATIONS:

• PhD in immunology or related field with minimum of 6 years relevant experience required
• Experience across multiple fields of immunology, such as deep knowledge of diverse cell types and disease areas required
• Track record of contributing to a cross-functional project team and enabling achievement of milestones as a leader and collaborative team player
• Deep understanding of flow cytometry and immunophenotyping with complex flow panels
• Previous experience designing pharmacology studies required
• Curious, detail oriented, eager to tackle hard problems, and ability to communicate complex issues effectively

POSITION: Full-Time, Exempt