Senior Scientist I/II

We are seeking a highly motivated, creative, and collaborative Senior Scientist I/II to join our Biological Sciences drug discovery group. This position will be responsible for designing, performing, coordinating, and interpreting structural biology, biochemical, biophysical, and cellular experiments for our drug discovery programs. This includes the development of relevant model systems for the identification, validation, and screening of compounds against novel therapeutic targets. The successful candidate will work independently, but also as an integral part of a larger team to achieve collective goals. The ideal candidate will have a deep understanding of biochemistry and structural biology and will apply this this to challenging ongoing and new drug discovery programs.

This position will report to a Senior Director, Biological Sciences, and work onsite at our research facility in Lawrence, Kansas.

What You’ll Do:

• Conceive, develop, and optimize biochemical and cellular assays to determine the therapeutic potential of rationally designed targeted small molecules
• Design and conduct rigorous experiments to identify and validate potential novel drug targets
• Work collaboratively with biologists, medicinal chemists, and external partners to deliver high quality structures of macromolecular complexes, custom proteins, and reagents
• Document experimental design, analysis, and interpretation of data in an ELN and LIMS system
• Stay abreast of the latest scientific and technological advancements in the field
• Author technical reports and presentations to communicate data and analyses effectively
• Add to Deciphera culture of collaboration and shared mission to solve complex biological problems
• Adhere to corporate policies including safety and compliance

Requirements

• A PhD in Biochemistry or related field with 4+ years of biotech or pharma industry experience
• An ability to think independently to design high-throughput experiments and generate robust, reproducible results
• Experience working with automated laboratory instruments including ECHO, Bravo, and multi-mode plate readers
• Expertise in biochemistry, HTS assay development, molecular biology, protein purification, X-ray crystallography or Cryo EM. Familiarity with biophysical techniques such as protein MS, SPR, ITC, MST, DSF is preferred
• Adaptability to work in a dynamic, fast-paced environment
• Excellent communication and presentation skills