Vice/Senior Vice President of Chemistry

About Rezo Therapeutics

Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.

Our Founders and members of the Board are a group of esteemed, world-class scientists from the University of California, San Francisco: Nevan Krogan, Kevan Shokat, Sourav Bandyopadhyay, Natalia Jura, as well as renowned biotech executives George Scangos and Norbert Bischofberger. These leaders bring with them a strong track record of amazing discoveries and scientific breakthroughs, leading to very successful companies and many FDA approved drugs.

Capitalizing on our Series A of $78M from top-tier investors, we are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.

Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements. If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us!

The Opportunity

We are seeking a strong and motivated Vice or Senior Vice President of Chemistry. This position is an excellent opportunity to be on the ground floor and help build this function from the very beginning.

What You'll Do:

• Lead multi-disciplinary drug discovery and development teams to IND-stage

• Build and lead a medicinal chemistry team in San Francisco and leverage external CRO partnerships to achieve project goals and timelines

• Develop and implement strategies to discover novel therapeutics, providing subject matter expertise in the field of chemistry with particular emphasis on first-in-class targets and emerging therapeutic modalities such as degraders, other bi-steric molecules, and covalent inhibitors

• Design high-quality small molecules considering SBDD, biological readouts, physicochemical properties, and pharmacological readouts

• Build, maintain, and grow productive relationships with internal and external colleagues in chemistry, structural biology, pharmacology, and computational biology

• Establish the intellectual property strategy working with internal and external patent counsel and lead the preparation of patent documents

• Provide leadership for peer-reviewed scientific publications and content for the non-clinical sections of regulatory submissions relevant to chemistry (e.g., information relevant to drug synthesis, formulation, analytical methods, and manufacturing processes)

About You:

• PhD in Chemistry or related area with 12+ years of experience in a biotech or pharmaceutical organization building teams and leading a group of chemists
• Strong medicinal chemistry skills with a proven track record of successfully driving campaigns in small molecule chemistry. Experience in the design and implementation of heterobifunctional molecules and molecular glues is highly desirable
• Demonstrated experience in lead identification to IND application
• Experience in taking on challenging new targets and the ability to adopt new approaches and therapeutic modalities
• Knowledge of biophysical characterization techniques including DLS, NTA, HPLC, CE, DSC, DSF, et al.
• Strong understanding of cGMP manufacturing guidelines
• Proven leadership and excellent communication, organizational, and interpersonal skills
• Extensive experience in small molecule drug discovery and a demonstrated track record of bringing small molecules from discovery to the clinic
• Familiarity with the application of cutting-edge molecular design tools, advanced synthesis routes, modern chemical biology techniques, and efficient purification approaches
• Experience managing academic and industrial external partners for outsourcing, licensing, and technology transfer
• Experience in chemical biology and the integration of structural biology and biophysics across mechanistic biology and drug development
• Experience in virtual screening and AI
• Strategic thinker capable of prioritizing and implementing the Foundation’s significant resources and the ability to influence/impact our mission
• A team player with strong organizational and multi-tasking skills
• Excellent written and oral communication skills

Compensation at Rezo

The expected starting salary range for this position based in San Francisco, California is $240,000-$360,000 for Vice President and $270,000-$400,000 for Senior Vice President. Actual starting salary will be determined based on multiple job-related factors including a candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

Benefits at Rezo

Medical (HMO or PPO), dental, and vision insurance

Discretionary time off policy

Company holidays (including summer and winter shutdown)

401(k) retirement savings program

Commuter / Mass Transit Benefit Program

Healthcare Flexible Spending Account (FSA)

Dependent care Flexible Spending Account (FSA)

Parental leave

Competitive compensation

Flexible work schedule

EEOC

At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws. This statement covers all facets of employment and is especially important when it comes to growing our team.

If you are wondering if you’ll belong at Rezo, or are worried that you don’t meet 100% of the qualifications for this role, take a chance on us and yourself — please apply!

SF Fair Chance Ordinance

Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.